Subacute toxicopathological evaluation of acephate toxicity and it’s amelioration by Swertia chirata in male Wistar rats: haemato-biochemical studies

Abstract

Study on subacute toxicopathological evaluation of Acephate and it’s amelioration by S. chirata was conducted in male Wistar rats. Thirty male rats were divided into 5 groups each comprising of 6 rats viz. (group I and III) kept as a control and plant control, group II (Acephate toxicated rats) & group IV and V (toxicated with Acephate and treated with S. chirata) and on 14th and 28th day haematobiochemical parameters were studied. Rats of group II and IV revealed significant reduction in Hb, TEC, PCV, TLC and delay the blood clotting time, where as, non-significant variation were observed in DLC. There was significant increase in serum glucose levels, AST, ALT, ALP, serum cholesterol, serum urea nitrogen in rats of group II and IV. Significant reduction in the levels of STP, serum sodium, serum potassium and serum AchE in rats of group II and IV was noted. These altered values showed improvement due to S. chirata (group V).