Effect of repeated oral administration of lead and repeated dermal exposure of λ-cyhalothrin alone and in combination on the hematological parameters in goats

Abstract

The present study was aimed to investigate the effect of lead and λ-cyhalothrin alone and in combination on different haematological parameters in goats. Sixteen healthy goats of either sex weighing 35-40 kg were divided in 4 groups (Group-A, B, C and D) with 4 goats in each group. Group-A goats were served as control. Group B goats were given lead-acetate @ 10 mg/kg B.W. (1/10 of LD50) orally daily for 28 days. Group C goats were received five dermal-applications (on day 0, 7, 14, 21 and 28) of λ-cyhalothrin @ 2.25mg/kg B.W. whereas group-D goats co-exposed to both lead acetate and λ-cyhalothrin in at same dose and route as in group-B and C. A significant decrease in TEC, PCV and Hb values were found in group-B and C goats as compared to control group. However, in lead-acetate treated goats of group-B a significant increase in TLC while λ-cyhalothrin group-C goats a significant decrease in TLC was found as compared to control group. Also a significant decrease in osmotic fragility of erythrocytes by lead-acetate and a significant increase in osmotic fragility of erythrocytes by λ-cyhalothrin were induced as compared to control group. The changes produced in haematological parameters are indicating that both the agents alone and their co-administration may be involved in free radicals generation.