Effectiveness of 1% curcumin gel subgingival application on interleukin-6 levels in chronic periodontitis patients

Abstract

Chronic periodontitis is inflammation caused by bacterial plaque that can cause periodontal tissue damage and ultimately cause tooth loss. In periodontitis patients, the production of proinflammatory cytokines such as IL-6 increases, these cytokines can influence the progression of periodontitis. The periodontitis treatment is mechanical therapy which is coupled with the administration of antimicrobial and anti-inflammatory drugs. Curcumin has antimicrobial and anti-inflammatory effects by increasing the production of IL-6 induced by lipopolysaccharides. This study aims to analyze the effectiveness of 1% curcumin gel subgingival application on IL-6 levels reduction before and after scaling and root planning. This study is experimental with pre and posttest control group design and is divided into 3 groups from 21 patients with chronic periodontitis. Each group before scaling and root planing was examined for IL-6 levels in the gingival crevicular fluid and then applied 1% curcumin gel, 0.2% chlorhexidine gel, without gel application and re-examined on the 7th day. IL-6 levels were analyzed by ELISA method. The data obtained were processed statistically using the Wilcoxon Test and T test with a significant value of p