Evaluation of il-6 levels after subgingival application Binahong leaf extract gel 3% on patients of chronic periodontitis

Abstract

Chronic periodontitis is an inflammatory disease which is characterized by the absence of pain and develops slowly, loss of attachment and resorption of bones that causes teeth to mobile and loose. Some markers responsible for the inflammatory process include cytokines, such as Interleukin-6 (IL-6), as one of the inflammatory cytokines, plays an important role in the inflammatory response of the periodontium. To handle the case of periodontitis, can be done by scaling and root planning (SRP) and can be combined with systemic ingredients and the application of herbal ingredients. One of the natural ingredients that has been used in wound healing is binahong leaves. In this study using 3% binahong leaves gel extract was applied to subgingival to reduce levels of IL-6 and periodontal status. In this study, using 16 samples, were divided into 2 groups: ie 8 samples as a test group, and 8 samples as a control group. IL-6 levels were examined after scaling and root smoothing. Statistically, there was a significant decrease in IL-6 levels in the gingival sulcus fluid after scaling and root planing (SRP) in periodontitis patients with ap values