Anti-oxidant Constituents from Corydalis govaniana Wall and C. casimiriana Duthie and Prain ex Prain

Abstract

Corydalis govaniana Wall. and C. casimiriana Duthie and Prain ex Prain., have been used in the treatment of syphilis, scrofula, cutaneous infections, along with diarrhea and dysentery. One tetrahydro-protoberberine type alkaloid, govaniadine (1); and six other alkaloids, caseadine (2), caseamine (3), protopine (4), stylopine (5), apocavidine (6), and fagarine I (7) were isolated from these two medicinal plants. Caseamine showed the best anti-oxidant (DPPH radical scavenging) activity (IC50 = 40.8 ± 0.9 µM). Govaniadine and caseadine showed moderate antioxidant activity (IC50 = 83.7 ± 1.7 µM), and IC50 = 75.7 ± 0.9 µM, respectively).