Evaluation of encapsulated catechin in chitosan- sodium tripolyphosphate nanoparticle

Abstract

In present study assessment of suitable drug delivery system for catechin using polymer of chitosan and its in vitro antioxidant were studied. Chitosan-tripolyphosphate forms ionic cross linkage. Particle size analysis revealed blank chitosan nanoparticle of size 392 nm and catechin loaded chitosan nanoparticle of size 324.4 nm. Encapsulation efficiency 69.17% and drug loading capacity 43.46% was recorded. In vitro release study revealed 9.74% release in simulated gastric fluid (SGF) and 23.58% release of catechin in simulated intestinal fluid (SIF).