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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Nature Immunology · 2020 · Vol. 21(11) · pp. 1336–1345

Yanchun Peng✉(Chinese Academy of Medical Sciences & Peking Union Medical College)Alexander J. Mentzer(Centre for Human Genetics)Guihai Liu(Capital Medical University)Xuan Yao(Chinese Academy of Medical Sciences & Peking Union Medical College)Zixi Yin(Chinese Academy of Medical Sciences & Peking Union Medical College)Danning Dong(Xinjiang Medical University)Wanwisa Dejnirattisai(University of Oxford)Timothy Rostron(University of Oxford)Piyada Supasa(University of Oxford)Chang Liu(Chinese Academy of Medical Sciences & Peking Union Medical College)César López‐Camacho(Centre for Human Genetics)Jose Slon-Campos(University of Oxford)Yuguang Zhao(University of Oxford)David I. Stuart(Centre for Human Genetics)Guido C. Paesen(Centre for Human Genetics)Jonathan M. Grimes(Centre for Human Genetics)Alfred A. Antson(University of York)Oliver W. Bayfield(University of York)Dorothy E. D. P. Hawkins(University of York)De‐Sheng Ker(University of York)Beibei Wang(Chinese Academy of Medical Sciences & Peking Union Medical College)Lance Turtle(University of Liverpool)Krishanthi Subramaniam(University of Liverpool)Paul Thomson(University of Liverpool)Ping Zhang(University of Oxford)Christina Dold(University of Oxford)Jeremy Ratcliff(University of Oxford)Peter Simmonds(University of Oxford)Thushan I. de Silva(University of Sheffield)Paul Sopp(University of Oxford)Dannielle Wellington(Chinese Academy of Medical Sciences & Peking Union Medical College)Ushani Rajapaksa(Chinese Academy of Medical Sciences & Peking Union Medical College)Yi‐Ling Chen(University of Oxford)Mariolina Salio(University of Oxford)Giorgio Napolitani(University of Oxford)Wayne Paes(University of Oxford)Persephone Borrow(University of Oxford)Benedikt M. Kessler(Chinese Academy of Medical Sciences & Peking Union Medical College)Jeremy Fry(ProImmune (United Kingdom))Nikolai F. Schwabe(ProImmune (United Kingdom))Malcolm G. Semple(University of Liverpool)J. Kenneth Baillie(University of Edinburgh)Shona C. Moore(University of Liverpool)Peter Openshaw(Imperial College London)M. Azim Ansari(University of Oxford)Susanna Dunachie(University of Oxford)Eleanor Barnes(University of Oxford)John Frater(University of Oxford)Georgina Kerr(University of Oxford)Philip Goulder(University of Oxford)Teresa Lockett(Oxford University Hospitals NHS Trust)Robert H. Levin(Worthing Hospital)Yonghong Zhang(Capital Medical University)Ru‐yang Jing(Capital Medical University)Ling‐Pei Ho(Chinese Academy of Medical Sciences & Peking Union Medical College)Eleanor Barnes(University of Oxford)Danning Dong(Xinjiang Medical University)Tao Dong(Chinese Academy of Medical Sciences & Peking Union Medical College)Susanna Dunachie(University of Oxford)John Frater(University of Oxford)Philip Goulder(University of Oxford)Georgina Kerr(University of Oxford)Paul Klenerman(University of Oxford)Guihai Liu(Capital Medical University)Andrew J. McMichael(Chinese Academy of Medical Sciences & Peking Union Medical College)Giorgio Napolitani(University of Oxford)Graham S. Ogg(Chinese Academy of Medical Sciences & Peking Union Medical College)Yanchun Peng(Chinese Academy of Medical Sciences & Peking Union Medical College)Mariolina Salio(University of Oxford)Xuan Yao(Chinese Academy of Medical Sciences & Peking Union Medical College)Zixi Yin(Chinese Academy of Medical Sciences & Peking Union Medical College)ISARIC4C Investigators(University of Edinburgh)J. Kenneth Baillie(Oxford University Hospitals NHS Trust)Paul Klenerman(University of Oxford)Alexander J. Mentzer(Centre for Human Genetics)Shona C. Moore(University of Liverpool)Peter Openshaw(University of Liverpool)Malcolm G. Semple(University of Liverpool)David I. Stuart(Centre for Human Genetics)Lance Turtle(University of Liverpool)Richard J. Cornall(University of Oxford)Christopher P. Conlon(Chinese Academy of Medical Sciences & Peking Union Medical College)Paul Klenerman(University of Oxford)Gavin Screaton(University of Oxford)Juthathip Mongkolsapaya(Siriraj Hospital)Andrew J. McMichael(Chinese Academy of Medical Sciences & Peking Union Medical College)Julian C. Knight(Centre for Human Genetics)Graham S. Ogg(Chinese Academy of Medical Sciences & Peking Union Medical College)Tao Dong(Chinese Academy of Medical Sciences & Peking Union Medical College)

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SARS-CoV-2 and COVID-19 Research COVID-19 Clinical Research Studies Long-Term Effects of COVID-19Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CD8ImmunologyVirologyAntibodyCoronavirusMedicineT cellImmunity

MeSH terms

BetacoronavirusCOVID-19SARS-CoV-2COVID-19 VaccinesAntigens, ViralUnited KingdomHumansImmunologic MemoryPneumonia, ViralViral VaccinesCD4-Positive T-LymphocytesImmunodominant EpitopesCoronavirus InfectionsCD8-Positive T-LymphocytesEpitopes, T-Lymphocyte