Evaluation of antimicrobial activity of ethanolic extract of Murraya koenigii against S. mutans

Abstract

Periodontal disease is a bacterial infection that affects the gums and bone supporting the teeth. The present study was aimed to evaluate the Antimicrobial activity of Murraya koenigii extract against Streptococcus mutans. Ethanol extract was subjected to phytochemical screening, thin layer chromatography, total phenolic content, antioxidant activity, antimicrobial activity. Phytochemical analysis of the extract of Murraya koenigii indicated the presence of phytochemicals such as flavvanoids, phenolics, alkaloids, and terpenoids. Thin layer chromatography was performed. Antioxidant assays were evaluated by assessing DPPH radical scavenging activity against standard butylated hydroxyanisole (BHA). From this study it can be concluded that Murraya koenigii shows significant antibacterial effect against gram positive S mutans. The Murraya koenigii were found to contain gallic acid and other phenolics which may be responsible for antibacterial activity. The studies will be explored for development of novel formulation using Murraya koenigii extract for periodontal diseases.