Synthesis of 6-aryl-7-arylazo-4-(N-substituted aminomethyl)-2H-thiazolo-[3, 2-a]-1, 3, 5-triazino-2-thiones as Antiviral Agents

Abstract

2-amino-4-aryl thiazole was diazotised with different aromatic amines to give 2-amino-4-aryl-5-arylazo thiazoles. These compounds were refluxed with ammonium thiocyanate and chloroacetyl chloride in acetone to afford N1-chloroacetyl-N3-(4-aryl-5-arylazothiazol-2-yl)-thioureas. These thioureas were cyclized in presence of POCl3 and PCl5 to give 6-aryl-7-arylazo-4-chloromethyl-2H-thiazolo-[3, 2-a]-1, 3, 5-triazino-2-thiones. These compounds were reacted with secondary amines in methanol to give title compounds 6-aryl-7-arylazo-4-(N-substituted aminomethyl)-2H-thiazolo-[3,2-a-]1,3,5-triazino-2-thiones.Antiviral nature of these compounds was studied against Ranikhet Disease Virus (RDV), Vaccinia Virus (VV) and Sunnhemp Rosette Virus (SRV). Some of these compounds have been found to be active against RDV and Vaccinia Virus.