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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

BMJ · 2020 · Vol. 370 · pp. m3339–m3339

Stephen R Knight✉(University of Edinburgh)Antonia Ho(MRC University of Glasgow Centre for Virus Research)Riinu Pius(University of Edinburgh)Iain Buchan(University of Liverpool)Gail Carson(University of Oxford)Thomas M Drake(University of Edinburgh)Jake Dunning(Public Health England)Cameron J Fairfield(University of Edinburgh)Carrol Gamble(University of Liverpool)Christopher Green(University of Birmingham)Rishi K Gupta(University College London)Sophie Halpin(University of Liverpool)Hayley Hardwick(University of Liverpool)Karl Holden(University of Liverpool)Peter Horby(University of Oxford)Clare Jackson(University of Liverpool)Kenneth A McLean(University of Edinburgh)Laura Merson(University of Oxford)Jonathan S. Nguyen‐Van‐Tam(University of Nottingham)Lisa Norman(University of Edinburgh)Mahdad Noursadeghi(University College London)Piero Olliaro(University of Oxford)Mark G. Pritchard(University of Oxford)Clark D Russell(The Queen's Medical Research Institute)Catherine A. Shaw(University of Edinburgh)Aziz Sheikh(University of Edinburgh)Tom Solomon(University of Liverpool)Cathie Sudlow(Health Data Research UK)Olivia Swann(University of Edinburgh)Lance Turtle(University of Liverpool)Peter Openshaw(Imperial College London)J. Kenneth Baillie(Roslin Institute)Malcolm G. Semple(University of Liverpool)Annemarie B Docherty(Edinburgh Royal Infirmary)Ewen M. Harrison(University of Edinburgh)

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Abstract

ISRCTN66726260.

COVID-19 Clinical Research Studies Sepsis Diagnosis and Treatment COVID-19 diagnosis using AICoronavirus disease 2019 (COVID-19)Protocol (science)Risk stratificationMedicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Stratification (seeds)Emergency medicineIntensive care medicineInternal medicine

MeSH terms

BetacoronavirusCOVID-19SARS-CoV-2AgedAged, 80 and overClinical ProtocolsFemaleUnited KingdomHospitalizationHumansMaleMiddle AgedPneumonia, ViralPredictive Value of TestsROC Curve