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A systematic review of neurological symptoms and complications of COVID-19

Journal of Neurology · 2020 · Vol. 268(2) · pp. 392–402

Xiangliang Chen✉(University of Cologne)Sarah Laurent(University of Cologne)Oezguer A. Onur(University of Cologne)Nina N. Kleineberg(University of Cologne)Gereon R. Fink(University of Cologne)Finja Schweitzer(University of Cologne)Clemens Warnke(University of Cologne)

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Abstract

The most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection with SARS-CoV-2. Although SARS-CoV-2 may have the potential to gain direct access to the nervous system, so far, SARS-CoV-2 was detected in the cerebrospinal fluid in two cases only. Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2 and to elucidate a possible impact of SARS-CoV-2 infection on common neurological disease, such as Alzheimer's, Parkinson's disease or multiple sclerosis.

Long-Term Effects of COVID-19 COVID-19 Clinical Research Studies COVID-19 and Mental HealthCoronavirus disease 2019 (COVID-19)NeuroradiologyNeurologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicinePandemicMEDLINEIntensive care medicineVirology