Natural bioactive products with antioxidant properties useful in neurodegenerative diseases

Abstract

Oxidative stress is one of the principal causes behind the progression of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, neurosclerosis and others. Reactive oxygen species and reactive nitrogen species are the major reduced moieties produced during the cellular oxidative stress which are responsible for the neural damage and death. Therefore, the compounds or group of compounds which are capable of limiting the concentration of these reduced form of oxygen commonly known as antioxidants can be the promising elements in controlling or recovering the neurodegenerative diseases. This article deals with various naturally active antioxidants which have been evidenced in the management of the neurodegenerative diseases. In this context, we have concluded the role of polyphenols, alkaloids, vitamins, terpenoids and several other bioactive compounds in the preventive and curative measures of different neurological disorders.