Evaluation of comparative Hypoglycaemic activity of ethanolic leaves extracts of datura stramonium and Eclipta alba

Abstract

Datura stramonium is a yearly plant belongs to family Solanaceae. Datura stramonium is generally known as jimson weed or thorn apple. Eclipta alba is commonly known as False Daisy or Bhringraj, a plant having a place with the family Asteraceae. Diabetes was produce in overnight fasted male Wistar rats (160-250 mg/kg) by interparitonial injection of 150 mg/kg body weight of alloxan. Alloxan monohydrate 150 mg/kg, b.w was dissolved in normal saline and injected I.P after 18 hours fasting. The rats were then given 4% w/v glucose solution in feeding bottle for the next 24 h in their cages to inhibit hypoglycemia. The rats will be divided into 7 groups of 6 animals each, total 42 animals used. Ethanolic extract of both plants (datura stramonium and eclipta alba) given in dose of 100, 200 mg/kg b.w and 200, 400 mg/kg b.w ethanolic extracts of both plants are administered orally for 14 days, in a single dose daily seven days after confirmation of hyperglycemia. Standard drug Glibenclamid & ethanolic leaves extracts of datura stramonium and eclipta Alba were administered orally for 14 days, in a single dose daily 7 days after confirmation of hyperglycemia. Significantly reversed decrease in body weight seen in diabetes. The dose of 200, mg/kg b.w /day of ethanolic extract of leaves datura and 400 mg/kg b.w/day of ethanolic extract of eclipta alba leaves were found to be having maximum activity.