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Cardiovascular manifestations and treatment considerations in COVID-19

Heart · 2020 · Vol. 106(15) · pp. 1132–1141
Yu Min KangTiffany ChenDavid MuiVictor A. FerrariDinesh JagasiaMarielle Scherrer‐CrosbieYucheng ChenYuchi Han

Abstract

Since its recognition in December 2019, covid-19 has rapidly spread globally causing a pandemic. Pre-existing comorbidities such as hypertension, diabetes, and cardiovascular disease are associated with a greater severity and higher fatality rate of covid-19. Furthermore, COVID-19 contributes to cardiovascular complications, including acute myocardial injury as a result of acute coronary syndrome, myocarditis, stress-cardiomyopathy, arrhythmias, cardiogenic shock, and cardiac arrest. The cardiovascular interactions of COVID-19 have similarities to that of severe acute respiratory syndrome, Middle East respiratory syndrome and influenza. Specific cardiovascular considerations are also necessary in supportive treatment with anticoagulation, the continued use of renin-angiotensin-aldosterone system inhibitors, arrhythmia monitoring, immunosuppression or modulation, and mechanical circulatory support.

COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 ResearchMedicineCardiogenic shockInternal medicineCardiologyMyocarditisCase fatality rateCardiomyopathyDiabetes mellitusAcute coronary syndromeImmunosuppression

MeSH terms

BetacoronavirusCytokine Release SyndromeAngiotensin-Converting Enzyme 2COVID-19SARS-CoV-2Angiotensin-Converting Enzyme InhibitorsAnticoagulantsCardiovascular DiseasesChloroquineDisseminated Intravascular CoagulationHumansHydroxychloroquineImmunosuppressive AgentsInfluenza, HumanPeptidyl-Dipeptidase A
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