Effect of platelet rich plasma in osteoarthritis knee-A short term follow up

Abstract

Introduction: Osteoarthritis (OA) is a painful chronic degenerative joint. As of now, there are less options available for patients with mild to moderate arthritis. Most of the approaches are palliative and address the symptoms rather than influencing the biochemical environment of the joint or the disease process.PRP is a newer treatment option emerging in the recent times and its efficacy needs to be examined in our population and hence the study.Materials and Methods: It is a prospective, observational, time bound, hospital-based study conducted from November 2017 to May 2019, after obtaining institutional Ethical committee approval. 60 primary OA knee joints, included in this study, selected from R L Jalappa Hospital and Research centre, Department of Orthopaedics, Kolar. Autologous PRP prepared and infiltration was done under strict aseptic conditions. Patients assessed with WOMAC scoring &VAS for pain, before giving the PRP injection & after giving the injection at periods of 1 month, 3 & 6 months. The decrease in WOMAC & VAS scores was suggestive of improvement in patient’s condition.Results: Significant difference was observed in mean VAS and WOMAC total scores. No local or systemic complications noted during the study period. The mean VAS score at baseline was 7.08 ± 0.79 and the decrease in mean VAS score continued up to six months follow-up that is 2.78 ±1.22 (P value