Effectiveness of platelet-rich plasma (PRP) in the treatment of mild to moderate knee osteoarthritis

Abstract

Aim: To assess the functional outcome of treatment of osteoarthritis knee joint by intra articular injection of platelet rich plasma.Methods: A total of 50 patients with grade 0 to grade 3 osteoarthritis knee joint were randomly selected and 2 doses of intraarticular injection of platelet rich plasma were given at interval of 1 month and the outcome was evaluated with visual analog scale (VAS) and the western Ontario and mcmaster universities arthritis index (WOMAC) at preinjection, 1,3 and 6 months interval. Results: The mean age of patients were 55.5. There were better improvements noted in VAS and WOMAC scale. Best scores were noted in 2 months interval. The scores got deteoriated over 6 months interval but the final scores were better than the pre injection scores. Two injection therapy gives better result than single injection therapy.Conclusion: Platelet rich plasma injection is effective in the treatment of osteoarthritis knee with minimum of two injections is appropriate therapies in treatment of osteoarthritis knee joint.