Study of adverse effects of different doses of dexmedetomidine when used with propofol: A comparative randomised controlled study

Abstract

Adverse Effects like Bradycardia and hypotension are the most common side-effects and can be described as an adverse exaggeration of their clinical advantages. Severe bradycardia leading to cardiac arrest has been reported with the use of dexmedetomidine. Other reported side effects are hypertension, nausea, vomiting, dry mouth, atrial fibrillation, pyrexia, chills, pleural effusion, atelectasis, pulmonary edema, hyperglycemia, hypocalcaemia, acidosis, etc. Rapid administration of dexmedetomidine infusion (loading dose of 1 µg/kg if given in less than 10 minutes) may cause transient hypertension. This study is an effort to find if there are any adverse effects of different doses of dexmedetomidine when used with propofol.