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The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans

Anesthesiology · 2000 · Vol. 93(2) · pp. 382–394

Thomas J. Ebert✉Judith Hall(University Hospital of Wales)Jill A. BarneyToni D. UhrichMaelynn D. Colinco

Abstract

Increasing concentrations of dexmedetomidine in humans resulted in progressive increases in sedation and analgesia, decreases in heart rate, cardiac output, and memory. A biphasic (low, then high) dose-response relation for mean arterial pressure, pulmonary arterial pressure, and vascular resistances, and an attenuation of the cold pressor response also were observed.

Anesthesia and Sedative Agents Veterinary Pharmacology and Anesthesia Intensive Care Unit Cognitive DisordersDexmedetomidineMedicineAnesthesiaHeart rateStroke volumeBlood pressureCentral venous pressureMean arterial pressureHemodynamicsCardiac output

MeSH terms

Adrenergic alpha-AgonistsAdultDose-Response Relationship, DrugDrug SynergismEpinephrineHemodynamicsHumansInfusions, IntravenousMaleGas Chromatography-Mass SpectrometryNorepinephrinePhenylephrinePressoreceptorsPsychometricsMental Recall

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