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A comparison of models for the analysis of the kinetics of drug release from PLGA-based nanoparticles
Heliyon · 2020 · Vol. 6(2) · pp. e03451–e03451
Leila Pourtalebi Jahromi(Shiraz University of Medical Sciences)Mohammad Ghazali(Shiraz University of Medical Sciences)Hajar Ashrafi✉(Shiraz University of Medical Sciences)Amir Azadi✉(Shiraz University of Medical Sciences)
Abstract
Most of the data sets present the highest R<sup>2</sup>, the lowest overall error and AIC for the Weibull model. Weibull model with the mean AIC = -36.37 and mean OE = 7.24 and the highest NE less than 5, 10, 15 and 20 % in most of the cases best fits the release data from various PLGA-based drug delivery systems that are studied. Weibull model seems to show enough flexibility to describe various release patterns PLGA provides.
Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsAkaike information criterionWeibull distributionPLGABioavailabilityFlexibility (engineering)Glycolic acidMathematicsBiological systemStatisticsNanoparticle
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References
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review
International Journal of Pharmaceutics · 2011 · 1,224 citations
PLGA-based nanoparticles: An overview of biomedical applications
Journal of Controlled Release · 2012 · 3,552 citations
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