Genotoxicity screening of Catharanthus roseus L extracts in Drosophila melanogaster M (Diptera: Drosophilidae)

Abstract

Alcoholic extract of the plant Catharanthus roseus L. is used in many traditional medicines to treat various diseases in many developing countries. Be that as it may, the symptoms and safety measures are not well studied and assessed. The present study aims to investigate major phytochemical constituents and genotoxic effect of the alcoholic extracts of C. roseus. The results showed that the exposure of C. roseus extract brought about considerable changes in protein profile of Drosophila melanogaster in both the doses such 1.5 & 0.1875 mg/ml. In lower doses (0.1875 mg/ml) five new proteins with apparent molecular weights 109, 45, 36, 28 and 11kDa were expressed. Disappearance many proteins especially higher molecular group and lower molecular group were recorded in lower dose. Hence, the plant extract should be evaluated for its long term human health hazards and wellbeing completely before it could be used for therapeutic medicinal interventions.