Nephroprotective and antioxidant activity of ethanol extract of whole plant Biophytum sensitivum (Linn.) dc on gentamicin-induced renal damage in rats

Abstract

Present study was undertaken to investigate nephroprotective and antioxidant activity of whole plant ethanol extract of Biophytum sensitivum Linn. DC on gentamicin induced-nephrotoxicity in Wistar albino rats. Animals were divided into five groups, containing six animals in each. Gentamicin 100mg/kg/day; i.p., was given to all groups except normal control to induce nephrotoxicity for a period of 8 days in rats. Animals in Group I served as control and Group II as GM-treated or nephrotoxic control. Group III received standard quercetin; group IV received low dose of extract (250mg/kg) and group V received high dose of extract (50mg/kg).Serum levels of blood urea nitrogen, uric acid, creatinine, total protein, albumin, sodium, potassium, calcium, magnesium and antioxidant enzyme activities were determined. This study substantiated and confirmed the ethno-medical usefulness of B. sensitivum as nephroprotective and antioxidant agent.