Nephroprotective potential of Cynara scolymus L. floral extract in cisplatin induced nephrotoxicity in rats

Abstract

The study was aimed to determine the alterations in antioxidant, biochemical and histopathological parameters in cisplatin (cDDP) induced nephrotoxicity and its protection by treatment with hydro-alcoholic extract of Cynara scolymus. Acute nephrotoxicity was induced by cDDP (12 mg/kg) in wistar rats. Nephrotoxic rats were treated with quercetin (50 mg/kg) and hydro-alcoholic floral extract (150 and 300 mg/kg body weight) by oral gavage. Cisplatin treatment elevated (P<0.05) the levels of blood urea nitrogen, creatinine, uric acid, malondialdehyde but lowered (P<0.05) total plasma proteins, total thiols, blood glutathione levels and antioxidant enzymes as compared to the control. Pre and post treatment with plant extract at 150 and 300 mg/kg attenuated the altered levels of various enzymatic and oxidative parameters in blood and renal tissue in a dose dependent manner. The extract attenuated the degenerative and necrotic changes of proximal convoluted tubules induced by cDDP which initiates the good nephroprotective potential of C. scolymus extract.