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Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway

Molecular and Cellular Endocrinology · 2019 · Vol. 500 · pp. 110628–110628
Huiwen RenYing ShaoCan WuXiaoyu MaChuan LvQiuyue Wang
Autophagy in Disease and TherapyMetabolism, Diabetes, and CancerSirtuins and Resveratrol in MedicineMetforminAMPKAutophagyFOXO1Sirtuin 1Oxidative stressEndocrinologyInternal medicineProtein kinase AAMP-activated protein kinase

MeSH terms

Forkhead Box Protein O1AnimalsAutophagyCells, CulturedDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NephropathiesMaleMetforminNerve Tissue ProteinsStreptozocinSignal TransductionOxidative StressMesangial CellsRats

Funding

  • Natural Science Foundation of Liaoning Province
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303
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