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HH-suite3 for fast remote homology detection and deep protein annotation

BMC Bioinformatics · 2019 · Vol. 20(1) · pp. 473–473
Martin SteineggerMarkus MeierMilot MirditaHarald VöhringerStephan J. HaunsbergerJohannes Söding

Abstract

The added functionalities and increased speed of HHsearch and HHblits should facilitate their use in large-scale protein structure and function prediction, e.g. in metagenomics and genomics projects.

Genomics and Phylogenetic StudiesMachine Learning in BioinformaticsProtein Structure and DynamicsComputer scienceHidden Markov modelSoftware suiteViterbi algorithmSoftwareAnnotationSuiteSmith–Waterman algorithmSequence alignmentThreading (protein sequence)

MeSH terms

AlgorithmsMarkov ChainsSoftwareSequence AlignmentSequence Analysis, ProteinMolecular Sequence Annotation

Funding

  • Michigan State University
  • College of Engineering, Michigan State University
  • Horizon 2020 Framework Programme
  • Horizon 2020
Citations
1,244
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References
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References
Fast and sensitive protein alignment using DIAMOND
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Bioinformatics · 2010 · 21,473 citations
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Nucleic Acids Research · 2000 · 39,191 citations
Accelerated Profile HMM Searches
PLoS Computational Biology · 2011 · 7,253 citations
Profile hidden Markov models.
Bioinformatics · 1998 · 5,777 citations
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