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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

Cell stem cell · 2019 · Vol. 25(4) · pp. 558–569.e7
Cleber A. TrujilloRichard GaoPriscilla D. NegraesJing GuJustin BuchananSebastian PreißlAllen WangWei WuGabriel G. HaddadIsaac A. ChaimAlain DomissyMatthieu VandenbergheAnna DevorG YeoBradley VoytekAlysson R. Muotri
Neural dynamics and brain functionPhotoreceptor and optogenetics researchMolecular Communication and NanonetworksOrganoidBiologyBrain developmentHuman brainNeuroscienceBrain wavesElectroencephalography

MeSH terms

Biological ClocksCells, CulturedCerebellar Cortexgamma-Aminobutyric AcidHumansNerve NetSynaptic TransmissionOrganoidsSignal TransductionNeocortexGene Expression ProfilingNeurogenesisInduced Pluripotent Stem CellsSingle-Cell AnalysisElectromagnetic Radiation

Funding

  • California Institute for Regenerative Medicine
  • National Alliance for Research on Schizophrenia and Depression
  • Simons Foundation Autism Research Initiative
  • National Institutes of Health
  • Kavli Institute for Brain and Mind, University of California, San Diego
Citations
925
FWCI
50.87
field-weighted impact
References
70
Percentile
100%
vs. same field & year
Citations per year
References
The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes
Nature reviews. Neuroscience · 2012 · 4,338 citations
Large-scale recording of neuronal ensembles
Nature Neuroscience · 2004 · 1,901 citations
Bursts as a unit of neural information: making unreliable synapses reliable
Trends in Neurosciences · 1997 · 1,437 citations
Abnormal neural oscillations and synchrony in schizophrenia
Nature reviews. Neuroscience · 2010 · 2,108 citations
Left frontal hypoactivation in depression.
Journal of Abnormal Psychology · 1991 · 747 citations
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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development · Scinovex