articleTop 10% cited

Left frontal hypoactivation in depression.

Journal of Abnormal Psychology · 1991 · Vol. 100(4) · pp. 535–545

Jeffrey B. Henriques✉(University of Wisconsin–Madison)Richard J. Davidson

Abstract

Baseline resting electroencephalogram activity was recorded with 3 different reference montages from 15 clinically depressed and 13 control subjects. Power in all frequency bands was extracted by fast Fourier transformation. There was a significant Group X Hemisphere interaction in the mid-frontal region, for the alpha band power only. Depressed subjects had less left-sided activation (i.e., more alpha activity) than did normal control subjects. This pattern of diminished left-sided frontal activation is interpreted as indicating a deficit in approach mechanisms in depressed subjects.

Neural and Behavioral Psychology Studies Functional Brain Connectivity Studies Creativity in Education and NeurosciencePsychologyAudiologyDepression (economics)Frontal lobeLateralization of brain functionElectroencephalographyBehavioral activationAlpha (finance)NeuroscienceRight hemisphere

MeSH terms

AdultArousalDepressive DisorderDominance, CerebralElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedSignal Processing, Computer-Assisted

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747

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4.43

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