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Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model

PLoS Computational Biology · 2017 · Vol. 13(1) · pp. e1005324–e1005324
Sheng WangSiqi SunZhen LiRenyu ZhangJinbo Xu

Abstract

http://raptorx.uchicago.edu/ContactMap/.

Protein Structure and DynamicsRNA and protein synthesis mechanismsMachine Learning in BioinformaticsResidualArtificial intelligenceDeep learningComputer sciencePairwise comparisonConvolutional neural networkProtein structure predictionCASPArtificial neural networkTransformation (genetics)

MeSH terms

Machine LearningAlgorithmsProtein ConformationProteinsNeural Networks, ComputerComputational BiologySequence Analysis, ProteinDatabases, Protein

Funding

  • National Science Foundation
  • Nvidia
  • National Institutes of Health
  • Directorate for Biological Sciences
  • National Institute of General Medical Sciences
Citations
977
FWCI
48.47
field-weighted impact
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57
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100%
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References
Critical assessment of methods of protein structure prediction (CASP) — round x
Proteins Structure Function and Bioinformatics · 2013 · 689 citations
Scoring function for automated assessment of protein structure template quality
Proteins Structure Function and Bioinformatics · 2004 · 2,431 citations
Correlated mutations and residue contacts in proteins
Proteins Structure Function and Bioinformatics · 1994 · 886 citations
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