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Proanthocyanidins: A comprehensive review

Biomedicine & Pharmacotherapy · 2019 · Vol. 116 · pp. 108999–108999

Abdur Rauf(University of Swabi)Muhammad Imran(University of Lahore)Tareq Abu‐Izneid(Al Ain University)Iahtisham-Ul-Haq(Imperial College of Business Studies)Seema Patel(San Diego State University)Xiandao Pan✉(Chinese Academy of Medical Sciences & Peking Union Medical College)Saima NazA. Sanches‐Silva(Instituto Nacional de Investigação Agrária e Veterinária)Farhan Saeed(Government College University, Faisalabad)Hafiz Ansar Rasul Suleria(University of Melbourne)

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Abstract

Proanthocyanidins are condensed tannins with various pharmacological properties. These phytochemicals are considered as 'offense and defense molecules because of their human health benefits. The validation of their diverse health aspects, namely, antioxidant, anticancer, antidiabetic, neuroprotective, and antimicrobial has earned them repute in thermochemistry. Proanthocyanidins are oligo- or polymers of monomeric flavan-3-ols produced as an end product of flavonoid biosynthetic pathway. Agricultural wastes and food processing wastes contain immense amount of proanthocyanidins, exploitation of which can be a sustainable source of dietary supplements and functional ingredients. The current review article discusses recent developments in the health promoting properties of proanthocyanidins and the associated hurdles.

Phytochemicals and Antioxidant Activities Natural Antidiabetic Agents Studies Metabolomics and Mass Spectrometry StudiesProanthocyanidinHealth benefitsChemistryHuman healthFlavonoidAntioxidantFood scienceAntimicrobialBiotechnologyBiochemistry