reviewTop 1% cited
Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges
Bioorganic & Medicinal Chemistry Letters · 2019 · Vol. 29(13) · pp. 1555–1564
Scott D. Edmondson✉(AstraZeneca (United States))Bin Yang(AstraZeneca (United States))Charlene Fallan(AstraZeneca (United Kingdom))
Protein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathwaysChemical spaceProteolysisChemistryComputational biologyDrug discoveryBiologyBiochemistry
MeSH terms
ChimeraHumansDrug DiscoveryProteolysis
Citations
382
FWCI
15.25
field-weighted impact
References
81
Percentile
99%
vs. same field & year
Citations per year
References
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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
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