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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

Bioorganic & Medicinal Chemistry Letters · 2008 · Vol. 18(22) · pp. 5904–5908

Ashley R. Schneekloth(Yale University)Mathieu Pucheault(Yale University)Hyun Seop Tae(Yale University)Craig M. Crews✉(Yale University)

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Protein Degradation and Inhibitors Peptidase Inhibition and Analysis Ubiquitin and proteasome pathwaysAndrogen receptorUbiquitin ligaseChemistryProteasomeReceptorProtein degradationUbiquitinAndrogenProteasome inhibitorMdm2

MeSH terms

Cell Membrane PermeabilityCell SurvivalHumansImidazolesIndicators and ReagentsPiperazinesProteinsReceptors, AndrogenBlotting, WesternUbiquitinProteomicsUbiquitin-Protein LigasesCell Line, TumorCell Proliferation

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584

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2.07

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87%

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