article Open AccessTop 1% cited
SignalP 5.0 improves signal peptide predictions using deep neural networks
Nature Biotechnology · 2019 · Vol. 37(4) · pp. 420–423
José Juan Almagro Armenteros✉(Technical University of Denmark)Konstantinos D. Tsirigos(Science for Life Laboratory)Casper Kaae Sønderby(University of Copenhagen)Thomas Nordahl Petersen(Technical University of Denmark)Ole Winther(University of Copenhagen)Søren Brunak(Technical University of Denmark)Gunnar von Heijne(Science for Life Laboratory)Henrik Nielsen(Technical University of Denmark)
Machine Learning in BioinformaticsRNA and protein synthesis mechanismsAntimicrobial Peptides and ActivitiesArtificial neural networkSignal peptideSIGNAL (programming language)Deep neural networksComputer scienceArtificial intelligenceComputational biologyCell biologyChemistryBiology
MeSH terms
AlgorithmsAmino Acid SequenceBacterial ProteinsBiotechnologySoftwareNeural Networks, ComputerComputational BiologyArchaeal ProteinsSequence Analysis, ProteinProtein Sorting SignalsEukaryota
Funding
- Novo Nordisk
- Novo Nordisk Fonden
Citations
4,608
FWCI
245.33
field-weighted impact
References
48
Percentile
100%
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Citations per year
Cited by
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References
A Combined Transmembrane Topology and Signal Peptide Prediction Method
Journal of Molecular Biology · 2004 · 2,493 citations
Long Short-Term Memory
Neural Computation · 1997 · 95,078 citations
SignalP 4.0: discriminating signal peptides from transmembrane regions
Nature Methods · 2011 · 9,102 citations
Prediction of lipoprotein signal peptides in Gram‐negative bacteria
Protein Science · 2003 · 1,103 citations
Amino acid substitution matrices from protein blocks.
Proceedings of the National Academy of Sciences · 1992 · 6,351 citations
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Nucleic Acids Research · 1997 · 74,154 citations
Improved Prediction of Signal Peptides: SignalP 3.0
Journal of Molecular Biology · 2004 · 6,350 citations
CD-HIT: accelerated for clustering the next-generation sequencing data
Bioinformatics · 2012 · 11,431 citations
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