Gastro protective effect of Momordica charantia in experimental corrosive gastric ulcer

Abstract

The purpose of our study is to assess the gastroprotective effect of Momordica charantia (MC) in gastric ulcer created with corrosive matter. The rats were treated after they were given corrosive matter; in Group 1, MC oil extract gavage (1 ml), and in Group 2 famotidine was given. Group 3 was the control group and did not receive any treatment. In histopathological examination, mucosal necrosis, edema, inflammation were assessed. The healing of corrosive induced gastric ulcer was found increased in treatment groups; ulcer scores were found as 3.6 (range 1-6) in Group 1, 3.7 (range 2-6) in Group 2 and 7.5 (range 6-8) in the control group. In paired comparison, significant difference was found in both treatment groups when compared with the control group in terms of necrosis width, p=0.024 and p=0.019 for Group 1 and 2, respectively. However, no difference was found between treatment groups regarding treatment efficiency (p=0.99).