Preliminary study on the ulcerogenic effect of the crude extract of aloe vera administered to ulcer-induced albino rats

Abstract

Introduction:Ulcer serious health issue associated with high risk of mortality and morbidity. This study was carried out to determine protective effects of Aloe vera in indomethacin induced ulcers in albino rats. rnMaterials and Methods:Albino rats were divided into four group five rats per group. Group I: control group, placed on food and water only. Group II: Indomethacin induced gastric ulcer. Group III: Aloe vera pre-treated.Group IV: Omeprazole pre-treated group. Liver enzymes, ulcer index and histological changes on the stomach were studied using standard methods.Results:There was an increased in the serum levels of AST and ALT while ALP levels decreased in gastric ulcer untreated. These enzymes were observed to be normal in Aloe vera pre-treated group and omeprazole pre-treated group. There was also a decreased level of serum bicarbonate and an increased level of serum chloride in the gastric ulcer untreated group when compared to Aloe vera pre-treated group and omeprazole pre-treated group. The mean ulcer indexes of the Aloe vera pre-treated and Omeprazole pre-treated were (0.36±0.074, ±0.074 mm) respectively. Aloe vera showed statistical significant gastro-protective activity (P < 0.05) similar to conventional drug (omeprazole). Conclusion: The resultsrevealed that Aloe vera extracts can be used to prevent ulcer.