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Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres

Pharmaceutical Research · 2000 · Vol. 17(1) · pp. 100–106

Karen K. Fu✉(Harvard–MIT Division of Health Sciences and Technology)Daniel W. Pack(University of Illinois Urbana-Champaign)Alexander M. Klibanov(IIT@MIT)Robert Langer(IIT@MIT)

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Advanced Drug Delivery Systems biodegradable polymer synthesis and properties Hydrogels: synthesis, properties, applicationsPLGAGlycolic acidPolymerChemistryLactic acidBiodegradable polymerDrug deliveryChemical engineeringMonomerConjugated system

MeSH terms

Polylactic Acid-Polyglycolic Acid CopolymerHydrogen-Ion ConcentrationMicrospheresPolyglycolic AcidPolymersDrug Delivery SystemsMicroscopy, ConfocalLactic Acid

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The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review