In vitro antimicrobial and cytotoxic activities of various methanolic fractions of Viburnum foetidum L. (Adoxaceae)

Abstract

The research was designed to determine the antimicrobial and cytotoxic activity of the wild edible species Viburnum foetidum (locally called motmoti, Family: Adoxaceae) found in hill tracts area of north-east Bangladesh and is used locally as a source of functional food. The dried course powder of the plant was extracted with MeOH (CME) and was partitioned to get petroleum ether (PETEF), Hexane (n-HF), chloroform (CHF), ethyl acetate (EAF) and aqueous fraction (AqF). The fractions were evaluated for antibacterial and cytotoxic potentials. All the extracts showed significant antimicrobial activity. The inhibition zone of CME was found to be 11-28 mm against bacteria and 18-20 mm against tested pathogenic fungi. In brine shrimp cytotoxicity assay PETEF, n-HF and CME showed significant lethality against shrimp nauplii with LC50 of 25, 25 and 39.81 µg/ml, respectively when compared to standard vincrinstine sulphate (10.44 µg/ml). All these data suggested that the plant might be a good source for natural antimicrobial and cytotoxic remedy.