Nephroprotective activity of Barleria longiflora L. (Acanthaceae) against gentamicin induced nephrotoxicity in male albino wistar rats

Abstract

Now a day’s acute renal failures and chronic renal failure are common and serious problems. Number of therapeutic proxies affects kidney ensuing acute renal failure. Herbal medicine has arisen as a skilled approach with serviceable values in treating various diseases and developing an affordable phytotherapy to treat severe kidney diseases. Most of Barleria species reveals a wide range of phytoconstituents and are potent in anti-inflamatory, analgestic, antileukemic, antitumor, antihyperglycemic, anti-amoebic, virudal, antidiabetic, antifertility, hepatoprotective, nephroprotective and antibiotic activities. The objective of this study is to endorse the nephroprotective activity of ethanol extract of Barleria longiflora against gentamicin induced nephrotoxicity in rats. Nephroprotective activity was assessed by determination of serum marker levels and kidney antioxidant markers. The drug was administered intraperitonialy at a dose of 100 mg/kg b.w. of gentamicin for 8 consecutive days. These increased levels of serum creatinine, blood urea, uric acid and extent of renal damage were decreased by the ethanol extract of Barleria longiflora.