Inhibition of calcium oxalate crystallization in vitro by methanolic leaf extract of Murraya koenigii (L.) Spreng

Abstract

Medicinal plants are old as human society for treatment, prevention or mitigation of diseases. Murraya koenigii (M. koenigii) is commonly known as curry plant, used in treatment or prevention of many diseases including kidney stone. The objective of this research was in vitro study on inhibition of calcium oxalate crystallization through titrimetric method. The results showed that greater inhibitory activity of M. Koenigii was found at 48 mg/ml (61.26%) while cystone showed maximum activity at 446 mg/ml (70.18%). Inhibitory activity of M. koenigii was concentration dependent manner which indicates the decrease of stone forming constituents. This activity of M. koenigii might be due to presence of secondary metabolites such as saponins and other phytoconstituents. Thus, it supports the knowledge of ethnomedicine in some tribes for prevention of kidney stone. And, in vivo study and chemical characterization of M. koenigii could be new candidate for treatment of kidney stone diseases in future.