Evaluation of anti-inflammatory, antibacterial and acaricidal activities of various leaf extracts of Pongamia pinnata

Abstract

Different leaf extracts of Pongamia pinnata i.e. aqueous, alcoholic, acetone and chloroform were investigated for in-vivo anti-inflammatory activity and in-vitro antibacterial and acaricidal activities at the dose rate of 50 mg/kg and 100 mg/kg. For determining anti-inflammatory activity carrageenan induced paw edema model was used. In-vitro antibacterial activity was assessed against clinical isolates of E.coli and S. aureus at the extract concentrations of 50 and 100 mg/ml. Fully engorged adult R. (B.) annulatus female ticks were collected from Bhatinda region of Punjab for determining acaricidal activity by AIT method. The results showed dose dependent anti-inflammatory activity with maximum reduction in oedema observed in the alcoholic extract group but no significant in-vitro antibacterial and acaricidal activities were recorded in the present study.