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A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

Journal of Antimicrobial Chemotherapy · 2017 · Vol. 73(4) · pp. 891–899

Anuradha Chowdhary✉(University of Delhi)Anupam Prakash(University of Delhi)Cheshta Sharma(University of Delhi)Milena Kordalewska(Rutgers, The State University of New Jersey)Anil Kumar(Amrita Vishwa Vidyapeetham)Smita Sarma(Medanta The Medicity)Bansidhar Tarai(Max Healthcare)Ashutosh Singh(University of Delhi)Gargi Upadhyaya(University of Delhi)Shalini Upadhyay(Medanta The Medicity)Priyanka Yadav(University of Delhi)Pradeep Kumar Singh(University of Delhi)Vikas Khillan(Institute of Liver and Biliary Sciences)Neelam Sachdeva(Rajiv Gandhi Cancer Institute and Research Centre)David S. Perlin(Rutgers Health)Jacques F. Meis(Radboud University Medical Center)

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Abstract

Overall, 25% and 13% of isolates were MDR and multi-azole resistant, respectively. The most common resistance combination was azoles and 5-flucytosine in 14% followed by azoles and amphotericin B in 7% and azoles and echinocandins in 2% of isolates.

Antifungal resistance and susceptibility Fungal Infections and Studies Pneumocystis jirovecii pneumonia detection and treatmentEchinocandinCandida aurisFluconazoleFlucytosineMicrobiologyEchinocandinsBiologyAmphotericin BAzoleCaspofungin

MeSH terms

Antifungal AgentsAzolesCandidaCandidiasisFemaleFungal ProteinsGenotypeHumansIndiaMaleMicrobial Sensitivity TestsMiddle AgedMutationSequence Analysis, DNAGene Expression Profiling

Funding

Indian Council of Medical Research
Astellas Pharma
National Institutes of Health

Citations

566

FWCI

28.97

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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References

Simultaneous Emergence of Multidrug-Resistant <i>Candida auris</i> on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

Clinical Infectious Diseases · 2016 · 1,583 citations

Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally

PLoS Pathogens · 2017 · 718 citations

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