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Simultaneous Emergence of Multidrug-Resistant <i>Candida auris</i> on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

Clinical Infectious Diseases · 2016 · Vol. 64(2) · pp. 134–140

Shawn R. Lockhart✉(Centers for Disease Control and Prevention)Kizee A. Etienne(Centers for Disease Control and Prevention)Snigdha Vallabhaneni(Centers for Disease Control and Prevention)Joveria FarooqiAnuradha Chowdhary(University of Delhi)Nelesh P. Govender(National Health Laboratory Service)Arnaldo Lopes Colombo(Universidade Federal de São Paulo)Belinda Calvo(University of Zulia)Christina A. Cuomo(Broad Institute)Christopher A. Desjardins(Broad Institute)Elizabeth L. Berkow(Centers for Disease Control and Prevention)Mariana Castanheira(JMI Laboratories)Rindidzani E. Magobo(National Health Laboratory Service)Kauser JabeenRana Jawad AsgharJacques F. Meis(Radboud University Nijmegen)Brendan R. Jackson(Centers for Disease Control and Prevention)Tom Chiller(Centers for Disease Control and Prevention)Anastasia P. Litvintseva(Centers for Disease Control and Prevention)

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Abstract

C. auris is an emerging healthcare-associated pathogen associated with high mortality. Treatment options are limited, due to antifungal resistance. WGS analysis suggests nearly simultaneous, and recent, independent emergence of different clonal populations on 3 continents. Risk factors and transmission mechanisms need to be elucidated to guide control measures.

Antifungal resistance and susceptibility Fungal Infections and Studies Antimicrobial Resistance in StaphylococcusCandida aurisFluconazoleCladeMultiple drug resistanceBiologyMedicineMolecular epidemiologyMicrobiologyDrug resistanceAntifungal

MeSH terms

Whole Genome SequencingAdolescentAdultAgedAntifungal AgentsCandidaCandidiasisChildChild, PreschoolCytochrome P-450 Enzyme SystemFemaleHumansInfantInfant, NewbornMale