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Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

The Lancet Neurology · 2017 · Vol. 16(12) · pp. 987–1048

Andrew I.R. Maas✉(University of Antwerp)David MenonP. David Adelson(Barrow Neurological Institute)Nada Anđelić(Oslo University Hospital)M. J. Bell(University of Pittsburgh)Antonio Belli(NIHR Surgical Reconstruction and Microbiology Research Centre)Peter Bragge(Monash University)Alexandra Bražinová(University of Trnava)András Büki(University of Pecs)Randall M. Chesnut(University of Washington)Giuseppe Citerio(Azienda Ospedaliera San Gerardo)Mark Coburn(RWTH Aachen University)D. James Cooper(University of Pecs)A. Tamara CrowderEndre Czeiter(University of Pecs)Marek Czosnyka(University of Cambridge)Ramon Diaz‐Arrastia(University of Pennsylvania)Jens P. Dreier(Charité - Universitätsmedizin Berlin)Ann‐Christine Duhaime(Harvard University)Ari Ercole(University of Pecs)Thomas A. van EssenValery L. FeiginGuoyi GaoJoseph T. GiacinoLaura E. González-LaraRussell L. GruenDeepak Gupta(University of Pecs)Jed A. HartingsSean HillJiyao JiangNaomi KetharanathanErwin J. O. KompanjeLinda LanyonSteven LaureysFiona LeckyHarvey S. LevinHester F. Lingsma(Erasmus MC)Marc MaegeleMarek Majdán(University of Trnava)Geoffrey T. ManleyJill A. MarstellerLuciana MasciaCharles McFadyenStefania MondelloVirginia NewcombeAarno PalotiePaul M. ParizelWilco C. Peul(Leiden University Medical Center)James PiercySuzanne Polinder(Erasmus MC)Louis Puybasset(Sorbonne Université)Todd E. RasmussenRolf Rossaint(RWTH Aachen University)Peter Smielewski(University of Cambridge)Jeannette A. E. SöderbergSimon Stanworth(NHS Blood and Transplant)Murray B. Stein(University of California San Diego)Nicole von SteinbüchelWilliam Stewart(Institute of Medical Microbiology and Hygiene)Ewout W. SteyerbergNino Stocchetti(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)Anneliese Synnot(La Trobe University)Braden Te AoOlli TenovuoAlice Theadom(Auckland University of Technology)Dick TibboelWalter Videtta(Hospital Posadas)Kevin Wang(University of Florida)W. Huw WilliamsLindsay Wilson(University of Stirling)Kristine Yaffe(University of California, San Francisco)Hadie AdamsVanni AgnolettiJudith AllansonKrisztina AmreinNorberto AndaluzAudny AnkeAnna Degli AntoniArjan Bastiaan van AsGérard AudibertA. AzaševacPhilippe AzouviMaria Luisa AzzoliniCamelia BaciuRafael BadenesKaren BarlowRonald BartelsUrsula BauerfeindMiriam H. BeauchampDarcy BeerRonny BeerF. J. BeldaBo‐Michael BellanderRémy BellierHabib BenaliThierry BénardValzerda BeqiriLuigi BerettaFrançis BernardGuido BertoliniFederico BilottaMorten BlaabjergHugo den BoogertKathy BoutisPierre BouzatBrian L. BrooksCaroline BrorssonMonika BullingerEmma BurnsEmiliana CalappiPeter CameronElsa CariseAna M. Castaño‐LeónFrancesco CausinGiorgio ChevallardArturo ChieregatoBrian R. ChristieMaryse C. CnossenJonathan ColesJohnny CollettFrançesco Della CorteWilliam CraigGábor CsatóÁkos CsomósNicola CurryClaire Dahyot‐FizelierHelen DawesCarol DeMatteoBart DepreitereDeborah DeweyJeroen van DijckĐula ĐilvesiDiederik W.J. DippelKemal DizdarevićEmma DonoghueOr DuekGuy‐Loup DulièreAdelaida DzekoGeorge A. EapenCarolyn A. EmeryShane EnglishPatrick EsserErzsébet EzerMartin FabriciusJunfeng FengDean FergussonAnthony FigajiJoanne M. FlemingKelly FoksGilles FranconyStephen B. FreedmanUlderico FreoShirin FrisvoldIsabelle GagnonDamien GalanaudDashiell GantnerB. GiraudBen GlockerJagoš GolubovićPedro A. GómezWayne A. GordonPrimož GradišekJocelyn GravelDonald GriesdaleFrancesca GrossiJuanita A. HaagsmaAsta K. HåbergIain HaitsmaWim Van HeckeRaimund HelbokEirik HelsethCaroline van HeugtenCornelia HoedemaekersStefan HöferLindsay HortonJiyuan HuiJilske HuijbenPeter J. HutchinsonBram JacobsMathieu van der JagtStefan JankowskiKoen JanssensBojan JelačaKelly JonesKonstantinos KamnitsasRafael KapšMladen KaranAri KatilaKirsi‐Maija KaukonenVéronique De KeyserRiku KivisaariAngelos G. KoliasBálint KolumbánKsenija KolundžijaDaniel KondziellaLars‐Owe KoskinenNoémi KovácsAndreas H. KramerDemetrios J. KutsogiannisTheodoros KyprianouAlfonso LagaresFrançois LamontagneRoberto LatiniFrançois LauzierIsaac LazarChristian LedigRolf LeferingValérie LegrandLeon LeviRoger LightfootAngels LozanoStephen MacdonaldSebastian MajorAlex ManaraPauline ManhesHugues MaréchalCostanza MartinoAlessandro MasalaSerge MassonJulia MatternBradford J. McFadyenCatherine McMahonMaureen O. MeadeBéla MeleghTomas MenovskyLynne MooreMarta CorreiaMaria Cristina Morganti-KossmannHolger MuehlanPratik MukherjeeLynnette MurrayJoukje van der NaaltAncuța NegruDavid NelsonDaan NieboerQuentin NoirhommeJózsef NyirádiMauro OddoDavid O. OkonkwoAnnemarie W. OldenbeuvingFabrizio OrtolanoMartin H. OsmondJean‐François PayenVincent PerlbargPaolo PersonaNicolas PichonAnna Piippo-KarjalainenSébastien Pili‐FlouryMatti PirinenHoria PleMaría A. PocaJussi P. PostiDominique Van PraagAlain PtitoAndreea RădoiArminas RagauskasRahul RajRuben RealNick ReedJonathan R. RhodesClaudia S. RobertsonSaulius RočkaCecilie RøeOlav RøiseGerwin RoksJonathan RosandJeffrey V. RosenfeldChristina RosenlundGuy RosenthalSandra RossiDaniel RueckertGodard C. W. de RuiterMarco SacchiBarbara J. SahakianJuan SahuquilloOliver SakowitzGerardo SalvatoRenán Sánchez-PorrasJános SándorGrinder SanghaNadine SchäferSilke SchmidtKathryn SchneiderDavid M. SchnyerHerbert SchöhlGuus SchoonmanRico Frederik SchouÖzcan SirToril SkandsenDirk SmeetsAbayomi SorinolaEmmanuel A. StamatakisAna StevanovicRobert D. StevensNina SundströmFabio Silvio TacconeRiikka TakalaPäivi TanskanenMark TaylorRalph TelgmannNancy TemkinGuido TeodoraniMatt ThomasChristos ToliasTony TrapaniAlexis F. TurgeonPeter VajkoczyAlex B. ValadkaEgils ValeinisShirley VallanceZoltán VámosAlessia VargioluEmmanuel VegaJan VerheydenAnne VikRimantas VilcinisCarmen Vleggeert‐LankampLidia VogtVictor VoloviciDaphne VoormolenPeter VulekovicThijs Vande VyvereJulia Van WaesbergheLars WesselsEno WildschutGuy WilliamsMaren K. L. WinklerStefan WolfGordon WoodNektaria XirouchakiAlexander YounsiMenashe ZaaroorVeronika ZelinkovaRoger ZemekFabrizio Zumbo

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Abstract

A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world's population will have one or more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries, with a disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has been estimated that TBI costs the global economy approximately $US400 billion annually. Deficiencies in prevention, care, and research urgently need to be addressed to reduce the huge burden and societal costs of TBI. This Commission highlights priorities and provides expert recommendations for all stakeholders—policy makers, funders, health-care professionals, researchers, and patient representatives—on clinical and research strategies to reduce this growing public health problem and improve the lives of people with TBI.

Trauma and Emergency Care Studies Traumatic Brain Injury Research Traumatic Brain Injury and Neurovascular DisturbancesTraumatic brain injuryPublic healthMedicinePopulationHealth careSocietal impact of nanotechnologyOccupational safety and healthYears of potential life lostInjury preventionGlobal health