reviewTop 1% cited
The diverse functions of the PD1 inhibitory pathway
Nature reviews. Immunology · 2017 · Vol. 18(3) · pp. 153–167
Arlene H. Sharpe✉(Harvard University)Kristen E. Pauken(Harvard University)
Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and InteractionAutoimmunityImmunotherapyT-cell receptorImmunologyT cellImmune systemBiologyImmunityCancer immunotherapyMajor histocompatibility complex
MeSH terms
Antineoplastic Agents, ImmunologicalAntibodies, MonoclonalB-LymphocytesHumansImmunotherapyKiller Cells, NaturalLymphocyte ActivationNeoplasmsT-LymphocytesSignal TransductionAutoimmunityProgrammed Cell Death 1 Receptor
Funding
- National Institutes of Health
Citations
1,942
FWCI
48.75
field-weighted impact
References
176
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Nature Medicine · 1999 · 2,463 citations
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
New England Journal of Medicine · 2015 · 9,308 citations
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
European Journal of Immunology · 2003 · 625 citations
Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8<sup>+</sup> T cell activation and cytolysis
European Journal of Immunology · 2003 · 473 citations
Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
Journal of Clinical Oncology · 2010 · 2,913 citations
PD‐1 signaling in primary T cells
Immunological Reviews · 2009 · 762 citations
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
Immunity · 2007 · 1,731 citations
Cancer Genome Landscapes
Science · 2013 · 7,937 citations
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