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Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

Immunity · 2007 · Vol. 27(1) · pp. 111–122

Manish J. Butte✉(Harvard University)Mary Keir(Harvard University)Theresa B. Phamduy(Harvard University)Arlene H. Sharpe(Harvard University)Gordon J. Freeman(Harvard University)

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Cancer Immunotherapy and Biomarkers CAR-T cell therapy research Immunotherapy and Immune ResponsesBiologyCell biologyProgrammed cell deathLigand (biochemistry)CellReceptorApoptosisBiochemistry

MeSH terms

AnimalsCell LineCells, CulturedChlorocebus aethiopsHumansLigandsMembrane GlycoproteinsMice, Inbred C57BLPeptidesProtein BindingT-LymphocytesDown-RegulationCytokinesB7-1 AntigenMice, Knockout

Funding

GlaxoSmithKline
Beth Israel Deaconess Medical Center
Harvard University
National Institutes of Health
National Institute of Allergy and Infectious Diseases
National Center for Research Resources

Citations

1,731

FWCI

22.81

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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References

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Nature Medicine · 1999 · 2,463 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8<sup>+</sup> T cell activation and cytolysis

European Journal of Immunology · 2003 · 473 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Nature Medicine · 2002 · 4,970 citations

Comparative Protein Modelling by Satisfaction of Spatial Restraints

Journal of Molecular Biology · 1993 · 13,125 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Nature Immunology · 2001 · 2,931 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

The Journal of Experimental Medicine · 2000 · 5,184 citations

THE B7 FAMILY REVISITED

Annual Review of Immunology · 2005 · 2,279 citations

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