articleTop 1% cited

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

Nature Methods · 2017 · Vol. 14(10) · pp. 959–962

M. Ryan Corces✉(Stanford University)Alexandro E. Trevino(Stanford University)Emily G. Hamilton(Stanford University)Peyton Greenside(Stanford University)Nicholas A. Sinnott‐Armstrong(Stanford University)Sam Vesuna(Stanford University)Ansuman T. Satpathy(Stanford University)Adam J. Rubin(Stanford University)Kathleen S. Montine(Stanford University)Beijing Wu(Stanford University)Arwa S. Kathiria(Stanford University)Seung Woo Cho(Stanford University)Maxwell R. Mumbach(Stanford University)Ava C. Carter(Stanford University)Maya Kasowski(Stanford University)Lisa A. Orloff(Stanford University)Viviana I. Risca(Stanford University)Anshul Kundaje(Stanford University)Paul A. Khavari(Stanford University)Thomas J. Montine(Stanford University)William J. Greenleaf(Chan Zuckerberg Initiative (United States))Howard Y. Chang(Stanford University)

View via DOI Publisher page

Genomics and Chromatin Dynamics Single-cell and spatial transcriptomics Cancer Genomics and DiagnosticsInterrogationProtocol (science)ChromatinComputer scienceContext (archaeology)Computational biologyProfiling (computer programming)DNABiologyMedicine

MeSH terms

AnimalsBrainCell LineDNAErythrocytesFreezingHumansSpecimen HandlingThyroid NeoplasmsKeratinocytesGene Expression Regulation, EnzymologicGenomeTransposasesSelf-Sustained Sequence ReplicationMice

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References

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Nature Methods · 2013 · 6,923 citations

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Genome biology · 2014 · 97,164 citations

An integrated encyclopedia of DNA elements in the human genome

Nature · 2012 · 19,173 citations

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