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The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

Movement Disorders · 2017 · Vol. 33(1) · pp. 88–98

Anna Heintz‐Buschart(University of Luxembourg)Urvashi Pandey(University of Luxembourg)Tamara Wicke(Philipps University of Marburg)Friederike Sixel‐Döring(Philipps University of Marburg)Annette Janzen(Philipps University of Marburg)Elisabeth Sittig‐Wiegand(Philipps University of Marburg)Claudia Trenkwalder(Paracelsus Elena Klinik Kassel)Wolfgang H. Oertel(Philipps University of Marburg)Brit Mollenhauer✉(Paracelsus Elena Klinik Kassel)Paul Wilmes✉(University of Luxembourg)

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Abstract

Our study reveals differential abundances of gut microbial taxa in PD and its prodrome idiopathic rapid eye movement sleep behavior disorder in comparison to the healthy controls, and highlights the potential of metagenomics to identify and characterize microbial taxa, which are enriched or depleted in PD and/or idiopathic rapid eye movement sleep behavior disorder. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Parkinson's Disease Mechanisms and Treatments Dysphagia Assessment and Management Gut microbiota and healthRapid eye movement sleepMicrobiomeREM sleep behavior disorderDiseaseAkkermansia muciniphilaAmplicon sequencingEye movementGut floraBiologyMedicine

MeSH terms

Gastrointestinal MicrobiomeAgedFemaleHumansMaleMiddle AgedNoseParkinson DiseaseRNA, Ribosomal, 16SRNA, Ribosomal, 18SCohort StudiesCase-Control StudiesREM Sleep Behavior Disorder