article Open AccessTop 1% cited
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
Nature Genetics · 2017 · Vol. 49(12) · pp. 1779–1784
Robin M. Meyers✉(Broad Institute)Jordan Bryan(Broad Institute)James M. McFarland(Broad Institute)Barbara A. Weir(Broad Institute)Ann E. Sizemore(Broad Institute)Han Xu(Broad Institute)Neekesh V. Dharia(Broad Institute)Phillip G. Montgomery(Broad Institute)Glenn S. Cowley(Broad Institute)Sasha Pantel(Broad Institute)Amy Goodale(Broad Institute)Yenarae Lee(Broad Institute)Levi D. Ali(Broad Institute)Guozhi Jiang(Broad Institute)Rakela Lubonja(Broad Institute)William F. Harrington(Broad Institute)Matthew R. Strickland(Broad Institute)Ting Wu(Broad Institute)Derek Hawes(Broad Institute)Victor Zhivich(Broad Institute)Meghan Wyatt(Broad Institute)Zohra Kalani(Broad Institute)Jaime J. Chang(Broad Institute)Michael Okamoto(Broad Institute)Kimberly Stegmaier(Broad Institute)Todd R. Golub(Broad Institute)Jesse S. Boehm(Broad Institute)Francisca Vázquez(Broad Institute)David E. Root(Broad Institute)William C. Hahn(Broad Institute)Aviad Tsherniak(Broad Institute)
CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesSingle-cell and spatial transcriptomicsCRISPRBiologyCas9Computational biologyGeneGeneticsGenomeGenome editingSubgenomic mRNA
MeSH terms
AlgorithmsHumansModels, GeneticNeoplasmsSensitivity and SpecificityReproducibility of ResultsGene DosageComputational BiologyGenetic Predisposition to DiseaseCell Line, TumorDNA Copy Number VariationsCRISPR-Cas Systems
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