Cardioprotective activity of Euphorbia hirta in Isoproterenol induced Myocardial Infarction in Rats

Abstract

Myocardial infarction is a major public health concern and the leading cause of death throughout the World. Considering the creditable medicinal benefits of Euphorbia hirta, the present study aimed to elucidate the cardioprotective effects of E. hirta leaf extract on isoproterenol induced myocardial infarction in rats. Prior administration of hydroethanolic leaf extract at 250 mg/kg of body weight was found to diminish the effect of isoproterenol on the levels of Total cholesterol, Triglycerides and LDL with a parallel rise in the level of HDL. The extract effect was compared with standard drug propranolol which also offered similar protection and it was further confirmed by histological changes of the heart. Thus our present study clearly indicated a significant cardioprotective activity of leaf extract due to the presence of phytochemicals and antioxidant properties.