Antibacterial Activity of an Isolated Compound (AC-1) from the Leaves of Ageratum conyzoides Linn.

Abstract

Antibacterial activity of an isolated compound (AC-1) from the leaves of Ageratum conyzoides Linn. wasrnevaluated against four Gram-negative bacteria like Escherichia coli, Shigella dysenteriae, Pseudomonas aeruginosarnand Salmonella typhi as well as four Gram - positive bacteria viz. Bacilliu subtilis, Bacilus megaterium,rnStaphylococcus aureus and Streptococcus pyogenes. Disc diffusion technique was used for in vitrornantibacterial screening. Result showed that compound AC-1 had large zone of inhibition in disc diffusionrnagainst the said bacteria. Antibacterial activity was more in Gram - positive bacteria than Gram - negative bacteria.rnHighest activity was noted against Staphylococcus aureus and lowest was found for Salmonella typhi. The MICrn(minimum inhibitory concentration) values of AC-1 against the bacteria ranged from 8 – 32 microgram/mL.rnResults, thus, suggests that the compound (AC-1) isolated from the leaves of Ageratum conyzoides Linn. had goodrnanti bacterial activity against the tested bacteria.