Sedative and Cytotoxic Properties of the leaf Extract of Desmodium paniculatum

Abstract

The present study was done to investigate the sedative and cytotoxic properties of methanol extract of Desmodium paniculatum Leaves. Sedative activity was evaluated by using hole cross, open field and thiopental sodium-induced sleeping time methods in swiss albino mice at 400 mg/kg body weight dose orally and the extract was evaluated by in-vitro brine shrimp lethality bioassay for investigating cytotoxic activity. The extract decreased the locomotor activity of mice in hole cross, open field test and minimize the onset of sleep and maximized the duration of sleeping time significantly (p