Combined wound healing activity of Calendula officinalis and Basil leaves

Abstract

The present study is to screen wound healing activity of carbopol gels prepared from hydro alcoholic extracts of Calendula officinalis (CE) and Ocimum basilicum Linn. (OE) in excision wound model and burn wound models in albino mice. Formulations of the extracts was prepared in the gels of carbopol individually and also in combination in equal ratio. In excision and burn wound models, the so treated animals showed significant reduction in period of epithelization and wound contraction and in combined gel showed accelerated wound healing activity. This may be due to synergism. The enhanced wound healing activity of hydro alcoholic extracts may be due to free radical scavenging action and the phytoconstituents present in it which either due to their individual or additive effect fastens the process of wound healing. Presence of flavonoids in alcoholic extracts was confirmed by phytochemical investigation and TLC methods.